Over the past 30 years or so, the world has “seen dramatic increases in obesity prevalence in all age groups.” This recent study from Barcelona, Spain analyzed the association of organochlorine compound exposure before birth, with speedy weight gain and obesity in infants. In the study, levels of various organochlorine compounds were assessed in the first trimester of pregnancy, and the weight of the babies were measured at frequent intervals. It was seen that exposure to organochlorine compounds within the womb is associated with rapid weight gain after birth.
Studies in the past have identified chemicals which cause increased weight gain in children. Such chemicals, also termed obesogenic chemicals, include bisphenol A, organotins, tobacco, hexachlorobenzene, etc. This study was conducted to recognize the growth-promoting actions of organochlorine compounds such as dichlorodiphenyldichloro-ethylene (DDE), hexachlorobenzene (HCB), Beta hexachlorohexane (bHCH) etc. Growth hormone-mimicking properties of some of these organochlorine compounds were proven at the end of the study using various statistical methods, thus holding these chemicals responsible for undue weight gain in affected babies.
In this study, maternal organochlorine compound assessment was performed only in the initial part of pregnancy. Levels of those compounds could have been estimated even at a later part of pregnancy, as there are many metabolic alterations during the later part of gestation. The sample size was modest; a larger group is necessary to confirm the findings of the present study. The infants’ growth was measured only up to 14 months; further follow-up of their growth is necessary.
This study proves that increased exposure of some organochlorine compounds during pregnancy is associated not only with faster growth of the child during the initial six months of life but also with increased chances of obesity later on. Organochlorine compounds, such as DDE, act at the genetic level to promote unusually high growth early in infancy and later. This study confirms the causal role of environmental pollutants like organochlorine compounds, especially DDE, in causing morbid diseases like obesity and other health hazards associated with them. The researchers state that, “More research exploring the potential role of chemical exposures in early onset obesity is needed.”
For More Information:
Association of Organochlorine Compound Exposure before Birth with Rapid Weight Gain and Overweight in Infancy
Environmental Health Perspectives, October 2010
By Michelle A. Mendez; Raquel Garcia-Esteban
From the Centre for Research in Environmental Epidemiology, Barcelona, Spain
The Municipal Institute of Medical Research, Barcelona, Spain
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain